High Fat Diet Changes Gene Expression

18 Jan

I have become increasingly interested in the effects of circadian rhythms on human behavior.

Science Abstracts

So over the holidays you threw moderation out the door with turkey with gravy, potato laktes and cheese blintzes or are about to overindulge on roasted pork for the year of the Snake.  You gained a few pounds but did anything else happen? Turns out it’s ‘YES’.


Reprogramming of the Circadian Clock by Nutritional Challenge

  • A high-fat diet reprograms the circadian transcriptome and metabolome
  • A high-fat diet impairs BMAL1 recruitment to target chromatin sites
  • Transcriptional reprograming involves PPARγ-driven oscillation in gene expression
  • Remodeling of the circadian clock by nutrients is rapid and reversible


Circadian rhythms and cellular metabolism are intimately linked. Here, we reveal that a high-fat diet (HFD) generates a profound reorganization of specific metabolic pathways, leading to widespread remodeling of the liver clock. Strikingly, in addition to disrupting the normal circadian cycle, HFD causes an unexpectedly large-scale genesis of de novo oscillating transcripts, resulting in…

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