A paper from Frontiers in Integrative Neuroscience reviews the evidence:
“Currently, several genetic and epidemiological studies have provided an overview of the inflammatory mechanisms involved in AD. Although the molecular basis of the disease remains unknown, the inflammation induced by Aβ has an important role in the neurodegenerative process. The inflammatory process itself is driven by microglial and astrocytic activation through the induction of pro-inflammatory molecules and related signaling pathways, thus leading to synaptic damage, neuronal loss, and the activation of other inflammatory participants.”
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