Treadmill Running Reverses Cognitive Declines due to Alzheimer’s Disease. In mice.

13 Jan

This study found that treadmill running could reverse cognitive decline in mice. More research will be needed before we know if these results will hold true for humans.

“Purpose: This study investigated the effect of treadmill running on cognitive declines in the early and advanced stages of Alzheimer’s disease (AD) in 3xTg-AD mice.

Methods: At 4 months of age, 3xTg-AD mice (N=24) were assigned to control (AD+CON, n=12) or exercise (AD+EX, n=12) group. At 24 months of age, 3xTg-AD mice (N=16) were assigned to AD+CON (n=8) or AD+EX (n=8) group. The AD+EX mice were subjected to treadmill running for 12-week. At each pathologic stage, the background strain mice were included as wild type control (WT+CON, n=8-12).

Results: At the early stage of AD, 3xTg-AD mice had impaired short- and long-term memory based on Morris water maze along with higher cortical A[beta] deposition, higher hippocampal and cortical tau pathology, and lower hippocampal and cortical PSD-95 and synaptophysin. A 12-week treadmill running reversed the impaired cognitive declines and significantly improved the tau pathology along with suppression of the decreased PSD-95 and synaptophysin in the hippocampus and cortex. At the advanced stage of AD, 3xTg-AD mice had impaired short- and long-term memory along with higher levels of A[beta] deposition, soluble A[beta]1-40 and A[beta]1-42, tau pathology, and lower levels of BDNF, PSD-95 and synaptophysin in the hippocampus and cortex. A 12-week treadmill running reversed the impaired cognitive declines and significantly improved the A[beta] and tau pathology along with suppression of the decreased synaptic proteins and BDNF in the hippocampus and cortex.

Conclusion: The current findings suggest that treadmill running provides a non-pharmacologic means to combat cognitive declines due to AD pathology.”

 

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