400 failed Alzheimer’s drugs

15 Jan

An article in The Washington Post examines why it is so hard to find an effective drug to treat Alzheimer’s disease:

These setbacks pile on to an already depressing situation: more than 400 failed clinical trials since the last Alzheimer’s drug — which only treats the symptoms of the disease, temporarily — was approved more than a decade ago.

(…)

Alzheimer’s is a formidable foe for a number of reasons. The brain isn’t easy to access, and much about how it works remains mysterious, even as scientific knowledge has moved forward. Doctors can’t take easy, repeat biopsies to see whether a drug is working.

Trials are long and expensive. It has become increasingly clear that it is necessary to treat patients early in the disease, and then wait to see if the disease is prevented or slowed.

Patients, though they are affected in heartbreaking ways, typically are unable to act as advocates for more funding or research when they are in the throes of the disease — unlike cancer or AIDS patients.

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