Neural oscillation refers to the rhythmic activity of large numbers of the brains neurons. It is these oscillations that produce the brain waves that are measured on a EEG. Here’s a recent paper suggesting that dyslexia may be caused by abnormal neural oscillation in parts of the brain related to auditory and visual processing. Here is the abstract:
It has been proposed that atypical neural oscillations in both the auditory and the visual modalities could explain why some individuals fail to learn to read and suffer from developmental dyslexia. However, the role of specific oscillatory mechanisms in reading acquisition is still under debate. In this article, we take a cross-linguistic approach and argue that both the phonological and orthographic specifics of a language (e.g., linguistic rhythm, orthographic depth) shape the oscillatory activity thought to contribute to reading development. The proposed theoretical framework should allow future research to test cross-linguistic hypotheses that will shed light on the heterogeneity of auditory and visual disorders and their underlying brain dysfunction(s) in developmental dyslexia, and inform clinical practice by helping us to diagnose dyslexia across languages.
Another interesting story about invertebrate brains, in this case the spider:
“Spiders are very smart, that’s why we’re studying them,” says Ronald Hoy, a professor of neurobiology and behavior at Cornell University. “They use visual cues to steer by, and the kind of mazes that they can solve is considered to be pretty impressive for an invertebrate.”
It was brought to my attention that education secretary nominee Betsy DeVos is an investor in a company that promises “brain enhancement. ” While visiting the site I found this amazing claim:
The cavemen had it right all along! Because bone broth is full of collagen (and 30% of our bodies’ protein consists of this), it acts as a “gut healer.” According to research by clinical nutritionist Dr. Josh Axe, gut health and brain health are highly connected to each other. And, gut-healing is said to help lower anxiety and other mood-related disorders.
I am almost speechless. Where to begin? I guess we could start by asking who the heck is Josh Axe? He is
a certified doctor of natural medicine, doctor of chiropractic and clinical nutritionist with a passion to help people get healthy by using food as medicine.
I have no special prejudice against chiropractors, but the DeVos affiliated website claims that he has conducted research. If he has, why aren’t links provided?
It is true that there is collagen in the brain, but it doesn’t follow from that that consuming collagen helps brain performance. Moreover there is evidence that bone broth may have high levels of the neurotoxin lead.
I always enjoyed reading the late Seth Robert’s blog. He never hesitated to question orthodoxies and always had some interesting new idea. However, some of the things he advocated were troubling. One example, of this was the butter brain hypothesis, the idea that consumption of butter might improve cognitive performance.
The idea is not implausible. The brain, after all, contains many lipids and the idea that consuming certain lipids might improve its performance does not sound unreasonable. The problem is butter is high in saturated fats and has been linked to heart disease.
I know, I know, many recent news reports tell us that “butter is safe” or that “butter is back.” These kind of person-bites-dog stories are popular in the media, but the science around saturated fats and cardiovascular disease is well established.
Here is an article from the New York Times reflecting on evolution and the dietary needs of the brain.
And here is a recent paper on the dangers of saturated fats. The abstract reads:
In recent years, many nutrition news headlines exclaimed that saturated fat was not linked to heart disease, leaving the public confused about whether to limit intake, as has been the dietary recommendation for several decades. However, a more nuanced look at the evidence indicates that high saturated fat diets are in fact not benign with respect to heart disease risk. Dietary recommendations should emphasize replacing saturated fats typical in red and processed meats, and certain tropical oils and dairy forms, with healthier polyunsaturated and monounsaturated fat-rich foods, such as nuts, olive oil, and fatty fish, as well as healthy sources of carbohydrates, such as fiber-rich whole-grain foods, rather than refined-grain and sugar-laden foods.
A paper published in PNAS titled “Magnetite pollution nanoparticles in the human brain,” makes the argument:
We identify the abundant presence in the human brain of magnetite nanoparticles that match precisely the high-temperature magnetite nanospheres, formed by combustion and/or friction-derived heating, which are prolific in urban, airborne particulate matter (PM). Because many of the airborne magnetite pollution particles are <200 nm in diameter, they can enter the brain directly through the olfactory nerve and by crossing the damaged olfactory unit. This discovery is important because nanoscale magnetite can respond to external magnetic fields, and is toxic to the brain, being implicated in production of damaging reactive oxygen species (ROS). Because enhanced ROS production is causally linked to neurodegenerative diseases such as Alzheimer’s disease, exposure to such airborne PM-derived magnetite nanoparticles might need to be examined as a possible hazard to human health.
It’s hard not the find the idea of pollution induced magnetite nanospheres in your brain disturbing. The paper reports:
The specific presence of magnetite in the brain is important because it has been causally linked with potential cellular responses to external magnetic fields
suggesting that the nanoparticles in conjunction with magnetic fields may be a factor. This may explain some of the inconsistent findings on the effects of magnetic fields on humans.
This story has received a lot of attention in media. The paper appeared in Nature, perhaps the most prestigious science journal in the world. Here is the abstract:
Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ. In a transgenic mouse model of AD, aducanumab is shown to enter the brain, bind parenchymal Aβ, and reduce soluble and insoluble Aβ in a dose-dependent manner. In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner. This is accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores. The main safety and tolerability findings are amyloid-related imaging abnormalities. These results justify further development of aducanumab for the treatment of AD. Should the slowing of clinical decline be confirmed in ongoing phase 3 clinical trials, it would provide compelling support for the amyloid hypothesis.
These are truly exciting results. The paper reports that a “dose-dependent slowing of clinical progression on the Mini Mental State Examination (MMSE) with aducanumab treatment was also observed.” In other words, the larger the dose the slower the cognitive decline. You can find details about Aducanumab here.