Tag Archives: Drugs

400 failed Alzheimer’s drugs

15 Jan

An article in The Washington Post examines why it is so hard to find an effective drug to treat Alzheimer’s disease:

These setbacks pile on to an already depressing situation: more than 400 failed clinical trials since the last Alzheimer’s drug — which only treats the symptoms of the disease, temporarily — was approved more than a decade ago.

(…)

Alzheimer’s is a formidable foe for a number of reasons. The brain isn’t easy to access, and much about how it works remains mysterious, even as scientific knowledge has moved forward. Doctors can’t take easy, repeat biopsies to see whether a drug is working.

Trials are long and expensive. It has become increasingly clear that it is necessary to treat patients early in the disease, and then wait to see if the disease is prevented or slowed.

Patients, though they are affected in heartbreaking ways, typically are unable to act as advocates for more funding or research when they are in the throes of the disease — unlike cancer or AIDS patients.

Breaking really bad – the Nazis and meth

28 Oct

An amazing piece in the Guardian about the Nazi’s use of drugs:

In 1940, as plans were made to invade France through the Ardennes mountains, a “stimulant decree” was sent out to army doctors, recommending that soldiers take one tablet per day, two at night in short sequence, and another one or two tablets after two or three hours if necessary. The Wehrmacht ordered 35m tablets for the army and Luftwaffe, and the Temmler factory increased production.

. . . the invasion of France was made possible by the drugs. No drugs, no invasion. When Hitler heard about the plan to invade through Ardennes, he loved it [the allies were massed in northern Belgium]. But the high command said: it’s not possible, at night we have to rest, and they [the allies] will retreat and we will be stuck in the mountains. But then the stimulant decree was released, and that enabled them to stay awake for three days and three nights. Rommel [who then led one of the panzer divisions] and all those tank commanders were high – and without the tanks, they certainly wouldn’t have won.”

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